Part One: Chemicals

Chemical Chinese name: Cyclohexanone

Chemical English name: Cyclohexanone

Main use: It is mainly used in the production of caprolactam and adipic acid, and is also an excellent solvent.

Part 2: Overview of Hazards

Hazard category: Class 3.3 high flash point flammable liquid

Invasion routes: inhalation, ingestion, transdermal absorption

Health hazards: This product has anesthetic and irritant effects.

Acute poisoning: The main symptoms include irritation of the mucous membranes of the eyes, nose, and throat, as well as dizziness, chest tightness, and general weakness. Severe cases may result in shock, coma, limb convulsions, pulmonary edema, and ultimately death due to respiratory failure. After detachment, it can quickly recover to normal. Liquids are irritating to the skin; Eye contact may cause corneal damage.

Chronic effects: Long term repeated exposure can cause dermatitis.   

Environmental hazards: Harmful to the environment.

Explosive hazard: This product is flammable and irritating.

Part Three: Composition/Composition Information

Main ingredients: Pure cyclohexanone content 99.5%

CAS number: 108-94-1

Relative molecular weight: 98.14

Molecular formula: C6H10O

Part Four: First Aid Measures

Skin contact: Remove contaminated clothing and thoroughly rinse the skin with soap and water.

Eye contact: Immediately lift the eyelids and thoroughly rinse with plenty of flowing water or saline solution for at least 15 minutes. Seek medical attention.

Inhalation: Quickly leave the scene and move to a place with fresh air. Keep the respiratory tract unobstructed. If breathing is difficult, administer oxygen. If breathing stops, immediately perform artificial respiration. Seek medical attention.

Ingestion: Drink plenty of warm water and induce vomiting. Seek medical attention.

Part 5: Fire Protection Measures

Hazardous characteristics: Flammable, with a risk of combustion when exposed to high heat or open flames. Reacts violently when in contact with oxidants.

Fire extinguishing method: Spray water to cool the container, and if possible, move the container from the fire scene to an open area. Extinguishing agent: foam, dry powder, carbon dioxide, sand.

Part 6: Emergency Response to Leakage

Quickly evacuate personnel from the contaminated area to a safe zone, isolate them, and strictly restrict their entry and exit. Cut off the fire source. It is recommended that emergency personnel wear self-contained positive pressure respirators and anti-static work clothes. Cut off the leakage source as much as possible. Prevent the flow into restricted spaces such as sewers and drainage ditches. Minor leakage: Absorb or absorb with sand or other non combustible materials. You can also rinse with a large amount of water, dilute the washing water, and put it into the wastewater system. Massive leakage: Construct embankments or dig pits to contain it. Cover with foam to reduce steam disaster. Transfer to a tanker or dedicated collector using an explosion-proof pump, and recycle or transport to a waste disposal site for disposal.

Part 7: Handling and Storage

Precautions for operation and disposal: Closed operation, pay attention to ventilation. Operators must undergo specialized training and strictly adhere to operating procedures. It is recommended that operators wear self-priming filter type gas masks (half masks), chemical safety goggles, anti-static work clothes, and rubber oil resistant gloves. Keep away from sources of fire and heat, and smoking is strictly prohibited in the workplace. Use explosion-proof ventilation systems and equipment. Prevent steam leakage into the workplace air. Avoid contact with oxidants and reducing agents. Charging should control the flow rate to prevent static electricity accumulation. Handle with care during transportation to prevent damage to packaging and containers. Equip with corresponding types and quantities of fire-fighting equipment and emergency response equipment for leaks. Empty containers may contain residual harmful substances. Store in a cool and ventilated warehouse. Stay away from sources of fire and heat. The storage temperature should not exceed 30 ℃. Keep the container sealed. It should be stored separately from oxidants, reducing agents, etc., and avoid mixing storage. Adopt explosion-proof lighting and ventilation facilities. Prohibit the use of mechanical equipment and tools that are prone to generating sparks. The storage area should be equipped with emergency response equipment for leaks and suitable containment materials.

Part 8: Exposure Control/Personal Protection

China MAC (mg/m3): 5

Former Soviet Union MAC (mg/m3): 10

US TLV-TWA: OSHA 50ppm, 200mg/m3; ACGIH 25ppm, 100mg/m3 [skin]

TLV-STEL in the United States: No data available

Monitoring method: gas chromatography; Furfural colorimetric method; Solvent desorption gas chromatography method

Engineering control: Closed operation, pay attention to ventilation.

Respiratory protection: When there is a possibility of exposure to its vapors, a self-priming filter type gas mask (half face mask) should be worn.

Eye protection: Wear chemical safety goggles.

Body protection: Wear anti-static work clothes.

Hand protection: Wear rubber oil resistant gloves.

Other protections: Smoking is strictly prohibited at the work site. Pay attention to personal hygiene and cleanliness. Avoid long-term repeated exposure.

Part 9: Physical and Chemical Characteristics

Appearance and shape: Colorless or light yellow transparent liquid with a strong pungent odor.

Flammability: Flammable

Flash point: 43

Ignition temperature: 420

Lower explosive limit%: 9.4

Explosion upper limit%: 1.1

Minimum ignition energy (mJ):

Maximum explosion pressure (Mpa):

Melting point (℃): -45

Boiling point (℃): 115.6

Relative density (water=1): 0.95

(Air=1): 3.38

Saturated vapor pressure (kPa): 1.33 (38.7 ℃)

Logarithmic value of octanol/water partition coefficient: 0.81

Combustion heat (kJ/mol): No data available

Critical temperature (℃): 385.9

Critical pressure (MPa): 4.06

Solubility: Slightly soluble in water, miscible in most organic solvents such as alcohols, ethers, benzene, acetone, etc.

Main use: It is mainly used in the production of caprolactam and adipic acid, and is also an excellent solvent.

Part 10: Stability and Reactivity

Stability: Stable

Aggregation hazard: non aggregation

Avoid contact conditions: open flames, high heat

Prohibited substances: Strong oxidizing agents, strong reducing agents, plastics.

Combustion (decomposition) products: carbon monoxide, carbon dioxide

Part 11: Toxicological Data

Acute toxicity: LD50: 1535 mg/kg (oral administration in rats); 948 mg/kg (rabbit transdermal)

LC50：32080mg/m3， 4 hours (inhaled by rats)

Irritation: 75ppm through the human eye, causing irritation. Rabbit percutaneous open stimulation test: 500mg, mild stimulation.

Experiment:

Subacute and chronic toxicity: no data available

Mutability: No data available

Microbial mutagenicity: No data available

Experiment: No data available

Reproductive toxicity: No data available

Carcinogenicity: No data available

Part 12: Ecological Data

Ecotoxicity: No data available

Biodegradability: No data available

Non biodegradable: No data available

Bioaccumulation: No data available

Part 13: Disposal of Waste

Waste nature: Hazardous waste.

Disposal method: Use controlled incineration method for disposal.

Disposal precautions: Before disposal, relevant national and local regulations should be consulted.

Part 14: Transportation Information

Dangerous Goods Number: 33590

UN number: 1915

Packaging classification: Class III packaging

Packaging label: Flammable liquid

Packaging method: Ordinary wooden box outside the ampoule bottle; Screw mouth glass bottles, iron cap pressed mouth glass bottles, plastic bottles, or ordinary wooden boxes outside metal drums (cans); Threaded glass bottles, plastic bottles, or tin plated steel drums (cans) are filled with bottom plate flower boxes, fiberboard boxes, or plywood boxes.

Transportation precautions: During transportation, the transport vehicle should be equipped with corresponding types and quantities of fire-fighting equipment and emergency response equipment for leaks. It is best to transport in the morning and evening during summer. The tank truck used for transportation should have a grounding chain, and a perforated partition can be installed inside the tank to reduce static electricity generated by vibration. It is strictly prohibited to mix and transport with oxidants, reducing agents, edible chemicals, etc. During transportation, it should be protected from direct sunlight, rain, and high temperatures. When stopping midway, one should stay away from sources of fire, heat, and high temperature areas. The exhaust pipe of the vehicle carrying the item must be equipped with a flame retardant device, and the use of mechanical equipment and tools that are prone to generating sparks for loading and unloading is prohibited. When transporting by road, follow the prescribed route and do not stay in residential or densely populated areas. It is prohibited to slip during railway transportation. It is strictly prohibited to use wooden boats or cement boats for bulk transportation.

Part 15: Regulatory Information

Regulatory information: Regulations on the Safety Management of Hazardous Chemicals (State Council Decree No. 591, implemented on December 1, 2011), Regulations on the Safe Use of Chemicals in the Workplace (issued by the Ministry of Labor and the Ministry of Chemical Industry on December 20, 1996), and other regulations have made corresponding provisions for the safe use, production, storage, transportation, loading and unloading of hazardous chemicals; The classification and hazard disclosure of commonly used hazardous chemicals (GB 13690-2009) classifies the substance as Class 3.3 high flash point flammable liquid.

Part 16: Other Information

References:

1. Zhou Guotai, Complete Book of Chemical Hazardous Materials Safety Technology, Chemical Industry Press, 1997

2. Compiled by the Toxic Chemicals Management Office of the National Environmental Protection Administration and the Beijing Institute of Chemical Technology, Environmental Data Manual for Chemical Toxicity Regulations, China Environmental Science Press, 1992